SBT may refer to:
- Sistema Brasileiro de Televisão (Brazilian Television System), a Brazilian TV network
- Scan-based trading, an inventory system
- State Bank of Travancore, a nationalised bank in India
- 2-sec-butyl-4,5-dihydrothiazole, a thiazoline ligand
- Single bullet theory, a theory of John F. Kennedy's assassination
- Small bowel transplantation
- Simple Build Tool, build tool for Scala
- South Bend Tribune newspaper, and its associated broadcast stations:
- Spontaneous breathing trial, abbreviation used in medical documents.
- Sym-Bionic Titan, an American animated series created by Genndy Tartakovsky for Cartoon Network.
- Staffordshire bull terrier
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