The 2008 Michigan vs. Toledo football game was a regular season college football game played on October 11, 2008. UT pulled off the biggest upset in program history as they defeated Michigan and becoming the first ever Mid-American Conference team to beat Michigan.
After their huge loss to Illinois, the Wolverines hosted the Toledo Rockets. It was the first time the two teams had ever played. In the first quarter, the Rockets scored first when a pass from Michigan QB Steven Threet was intercepted in the end zone by Tyrrell Herbert and run back 101 yards for a touchdown. Later in the first quarter, the Wolverines got on the board with 27-yard TD pass from Steven Threet to Brandon Minor. The next score came on a 26-yard K.C. Lopata field goal midway through the second quarter. With that, the teams went into the locker rooms at the half with a score of 10–7. In the second half, the Rockets shut out the Wolverines and scored two more field goals, both by Alex Steigerwald. He completed a 29-yard attempt in the third quarter and a 48-yard attempt in the fourth quarter. With less than a minute remaining in the game, the Wolverines got into the red zone and attempted a field goal to take the game into overtime. Lopata missed the field goal though, sealing the victory for the Rockets and marking the first time the Wolverines had ever lost to a Mid-American Conference team. Nick Moore of the Rockets set a record of 20 receptions against The Wolverines. With the loss, the Wolverines fell to 2–4, their worst start in 41 years.